Hemoglobin E, malaria and natural selection
نویسندگان
چکیده
منابع مشابه
Hemoglobin E prevalence in malaria-endemic villages in Myanmar.
The population of Myanmar comprises 8 major indigenous races (Bamar, Kayin, Kachin, Shan, Rakhine, Mon, Chin, and Kayah). The Bamar reside in the 7 central divisions of the country, and the others reside in the 7 peripheral states that border neighboring countries, including China, Laos, and Thailand in the east and India and Bangladesh in the west. Both malaria and HbE are endemic in Myanmar, ...
متن کاملEffects of Cryptolepine, 2, 7, dibromocryptolepine and standard drugs on hemoglobin accumulation in cultured Malaria parasites
Cryptolepine is the major alkaloidal constituent of the West African climbing shrub Cryptolepis sanguinolenta, a species used in traditional medicine for the treatment of malaria and a number of other infectious diseases. Cryptolepine and a number of its synthetic analogues have been shown to have potent antiplasmodial activities using P. falciparum lactate dehydrogenase assay (PfLDH). Intraery...
متن کاملThe hemoglobin E syndromes. I. Hemoglobin E in Eti-Turks.
With the technical assistance of Kaniil Tanrikulu H EMOGLOBIN E has been found with variable frequency among peopies of southeast Asia, such as the Thais,’ ’” the Burmese,2 the Malasians,3 the Indonesians,4 ”4’ the Bengalis,5#{176}’5” and Filipinos,6 and Vcddas of Ceylon.T37h Sporadic cases have been encountered in other countries.6’8 In 1955 an example of the hemoglobin E trait was discovered ...
متن کاملEffects of Cryptolepine, 2, 7, dibromocryptolepine and standard drugs on hemoglobin accumulation in cultured Malaria parasites
Cryptolepine is the major alkaloidal constituent of the West African climbing shrub Cryptolepis sanguinolenta, a species used in traditional medicine for the treatment of malaria and a number of other infectious diseases. Cryptolepine and a number of its synthetic analogues have been shown to have potent antiplasmodial activities using P. falciparum lactate dehydrogenase assay (PfLDH). Intraery...
متن کاملEpistatic Interactions between Apolipoprotein E and Hemoglobin S Genes in Regulation of Malaria Parasitemia
Apolipoprotein E is a monomeric protein secreted by the liver and responsible for the transport of plasma cholesterol and triglycerides. The APOE gene encodes 3 isoforms Ɛ4, Ɛ3 and Ɛ2 with APOE Ɛ4 associated with higher plasma cholesterol levels and increased pathogenesis in several infectious diseases (HIV, HSV). Given that cholesterol is an important nutrient for malaria parasites, we examine...
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ژورنال
عنوان ژورنال: Evolution, Medicine, and Public Health
سال: 2019
ISSN: 2050-6201
DOI: 10.1093/emph/eoz034